“The presence of a haemoglobin variant with high oxygen affinity would usually lead to polycythaemia, unless the high-affinity haemoglobin is also very unstable, e.g. Hb Koln. In fact, about one-third of unstable haemoglobins show an increased oxygen affinity. However, since the dominant feature is haemolysis rather than polycythaemia, they are categorized as unstable haemoglobin rather than as high-affinity haemoglobin.”

http://www.fmshk.com.hk/hkabth/em/dec2001.htm

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