Read about Hemoglobin Koln at the Blood Journal

Symptoms

Thalassemia
Heinz-body hemolytic anaemia
Bohr effect
Chronic ulcers on legs (Ref: betaZeroThalassemia496.pdf)
Hypochromia (Ref: betaZeroThalassemia496.pdf)
Sickling syndrome (Ref: betaZeroThalassemia496.pdf, Hb S beta thalassemia compound)
Erythrocytosis (Ref: betaZeroThalassemia496.pdf)
Thrombocytosis (Ref: betaZeroThalassemia496.pdf)
Jaundice (kolnSpontaneuosMutation715.pdf)
Fatigue (kolnSpontaneuosMutation715.pdf)
Dark urine (kolnSpontaneuosMutation715.pdf)
Splenomegaly (kolnSpontaneuosMutation715.pdf)
Polycythemia (kolnSpontaneuosMutation715.pdf)
Left Shift of Oxygen Dissociation Curve (kolnSpontaneuosMutation715.pdf)
Potassium loss, sodium accumulation (kolnSpontaneuosMutation715.pdf, intracellular dehydration)
Reticulocytosis (kolnCytoplasmHeinzBodies886.pdf)
Unconjugated hyperbilirubinemia (kolnCytoplasmHeinzBodies886.pdf)
Chronic hemolysis (Oxygen Affinity in Hemoglobin Köln Disease398.pdf)
Dipyrroluria (Oxygen Affinity in Hemoglobin Köln Disease398.pdf)
High oxygen affinity (Oxygen Affinity in Hemoglobin Köln Disease398.pdf)
Cyanosis (Structure-function relations of human hemoglobins)
Pigmenturia (Structure-function relations of human hemoglobins)
Drug intolerance (Structure-function relations of human hemoglobins)
Priapism
Renal failure

Treatments
Hemolytic anaemia - transfusions (Ref: betaZeroThalassemia496.pdf)
Splenectomy (Ref: kolmErythrocyteMembranes1263.pdf)
Phlebotomy

Current treatments for sickle cell disorders include administration of compounds such as antisickling agents

(e.g. hydroxyurea), erythropoietin, and/or antibiotics (e.g. ceftriaxone and erythromycin).

Current treatments for sickle cell diseases include, for example, administration of compounds such as

antisickling agents (e.g. hydroxyurea), erythropoietin, and/or antibiotics (e.g. ceftriaxone and

erythromycin), and allogenic bone marrow transplantation.

Other notes
Multiple forms of koln can coexist in one individual (Ref: betaZeroThalassemia496.pdf)